Immunodetection of human CRNN using CRNN polyclonal antibody (Cat # PAB13784) at 1 : 100 dilution. Staining performed on frozen sections of esophagus (A, B), foreskin (C, D) and scalp (E, F). Cornulin is expressed in the outer most layer of scalp skin and in the inner root sheat of the hair follicle, in normal esophagus, the staining is localized in the upper spinous and granular layers with strong peripheral localization. Control sections (B, D, F) show no staining.
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq
53 kDa squamous epithelial-induced stress protein,OTTHUMP00000014323,squamous epithelial heat shock protein 53,tumor-related protein