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Last updated: 2017/3/19
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CARD11 polyclonal antibody

  • Catalog # : PAB13783
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against CARD11.
  • Immunogen:
  • Amino acids 1-221 human CARMA1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • Recognizes CARMA1. Detects a band of ~130 KDa by Western blot.
  • Form:
  • Liquid
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In neat serum
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis of CARD11 by CARD11 polyclonal antibody (Cat # PAB13783). Jurkat T cells (8 X 106) were activated with CD3 monoclonal antibody (TR66, 10 ug/mL) and protein distribution of lipid raft (R) or non-raft (S) fractions was analyzed by detergent fractionation and immunoblotting (1 : 2,000) with CARD11 in nontransfected Jurkat T cells.
  • Immunohistochemistry
  • Immunocytochemistry
  • Immunofluorescence
  • Immunofluorescence
  • Immunohistochemistry analysis of CARD11 by CARD11 polyclonal antibody (Cat # PAB13783). Human T cells (clone 6396p5.1.2) were incubated with CD3 monoclonal antibody. Cells were stained for CD3 (green), phosphotyrosine (red) and CARD11 polyclonal antibody (Cat # PAB13783) (1 : 100 dilution; blue) and analyzed by confocal microscopy.
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Immunohistochemistry
  • Immunocytochemistry
  • Gene Information
  • Gene Name:
  • CARD11
  • Gene Alias:
  • BIMP3,CARMA1,MGC133069
  • Gene Description:
  • caspase recruitment domain family, member 11
  • Gene Summary:
  • The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000024641,bcl10-interacting maguk protein 3,card-maguk protein 1
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