Immunodetection of transfected human TNFRSF21 in HEK 293 cells using TNFRSF21 polyclonal antibody (Cat # PAB13779). Asterisks (*) represent N-glycosylated forms and arrow shows unglycosylated form of TNFRSF21.
Immunocytochemical analysis of transfected human TNFRSF21 in HEK 293 cells using TNFRSF21 polyclonal antibody (Cat # PAB13779). Confocal microscopy shows membrane localization of TNFRSF21 (nuclei stained was with anti-DRAQ5).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq
OTTHUMP00000016561,OTTHUMP00000039915,TNFR-related death receptor 6,death receptor 6