Western blot analysis of cell and tissue lysates with SCN1B polyclonal antibody (Cat # PAB13688). Lane 1 : Rat brain tissue. Lane 2 : Rat testicular tissue. Lane 3 : MCF-7. Lane 4 : HeLa. Lane 5 : MM231. Lane 6 : HT-1080.
Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM
sodium channel beta-1 subunit,sodium channel, voltage-gated, type I, beta polypeptide