PLN polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot of rat heart tissue lysate with PLN polyclonal antibody (Cat # PAB13686).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PLN.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human PLN.
Host
Rabbit
Theoretical MW (kDa)
6.1
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot of rat heart tissue lysate with PLN polyclonal antibody (Cat # PAB13686). -
Gene Info — PLN
Entrez GeneID
5350Gene Name
PLN
Gene Alias
CMD1P, PLB
Gene Description
phospholamban
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq
Other Designations
OTTHUMP00000017092|cardiac phospholamban
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Interactome
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Pathway
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Disease
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Publication Reference
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The human phospholamban gene: structure and expression.
McTiernan CF, Frye CS, Lemster BH, Kinder EA, Ogletree-Hughes ML, Moravec CS, Feldman AM.
Journal of Molecular and Cellular Cardiology 1999 Mar; 31(3):679.
Application：WB-Ti, Human, Human hearts.
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The human phospholamban gene: structure and expression.
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