MTNR1A polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
MTNR1A polyclonal antibody (Cat # PAB13671) (0.3 ug/mL) staining of KellyY cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MTNR1A.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human MTNR1A.
Sequence
C-SLKYDKLYSSKNS
Host
Goat
Theoretical MW (kDa)
39.4
Reactivity
Human
Specificity
Approximately 45 KDa band observed in lysates of cell line KELLY (calculated MW of 39.4 KDa according to NP_005949.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
MTNR1A polyclonal antibody (Cat # PAB13671) (0.3 ug/mL) staining of KellyY cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MTNR1A
Entrez GeneID
4543Protein Accession#
NP_005949.1Gene Name
MTNR1A
Gene Alias
MEL-1A-R, MT1
Gene Description
melatonin receptor 1A
Omim ID
600665Gene Ontology
HyperlinkGene Summary
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq
Other Designations
melatonin receptor type 1A
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Interactome
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Pathway
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Disease
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Publication Reference
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Melatonin suppresses nighttime memory formation in zebrafish.
Rawashdeh O, de Borsetti NH, Roman G, Cahill GM.
Science 2007 Nov; 318(5853):1144.
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Melatonin suppresses nighttime memory formation in zebrafish.
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