GCKR polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GCKR.
Immunogen
A synthetic peptide corresponding to human GCKR.
Sequence
KRFQHVIETPEPGK-C
Host
Goat
Theoretical MW (kDa)
68.7
Reactivity
Mouse, Rat
Specificity
Approximately 70 KDa band observed in mouse and rat liver lysates (calculated MW of 68.7 KDa according to human NP_001477.1 and of 68.9 KDa according to rat NP_037252.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GCKR polyclonal antibody (Cat # PAB13669) (0.1 ug/mL) staining of rat liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GCKR
Entrez GeneID
2646Protein Accession#
NP_001477.1Gene Name
GCKR
Gene Alias
GKRP
Gene Description
glucokinase (hexokinase 4) regulator
Omim ID
600842Gene Ontology
HyperlinkGene Summary
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq
Other Designations
glucokinase (hexokinase 4) regulatory protein|glucokinase regulator|glucokinase regulatory protein|hexokinase 4
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Interactome
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Disease
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Publication Reference
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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, Wahlstrand B, Hedner T, Corella D, Tai ES, Ordovas JM, Berglund G, Vartiainen E, Jousilahti P, Hedblad B, Taskinen MR, Newton-Cheh C, Salomaa V, Peltonen L, Groop L, Altshuler DM, Orho-Melander M.
Nature Genetics 2008 Jan; 40(2):189.
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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
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