PRKCE polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRKCE.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 721-737 of human PRKCE.
Sequence
NQEEFKGFSYFGEDLMP
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
These rabbit polyclonal antibodies are made against specific peptide regions of the PKC epsilon protein. By using specific peptides for the PKC delta that has effectively minimized cross reactivity between the various isoforms. These antibodies are useful in the screening of PKC epsilon proteins in various biological tissues and tumorigenesis studies.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Enzyme Immunoassay
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Gene Info — PRKCE
Entrez GeneID
5581Gene Name
PRKCE
Gene Alias
MGC125656, MGC125657, PKCE, nPKC-epsilon
Gene Description
protein kinase C, epsilon
Omim ID
176975Gene Ontology
HyperlinkGene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq
Other Designations
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Interactome
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Publication Reference
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Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.
Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF.
The Journal of Biological Chemistry 1993 Sep; 268(27):20110.
Application：WB-Ce, Mouse, Mouse myeloid progenitor 36D cells.
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Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.
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