Rabbit polyclonal antibody raised against recombinant PLAU.
Recombinant protein corresponding to human PLAU.
This polyclonal antibody is specific to human uPA (urokinase) and is useful for fibrnolytic and cancer studies. It is provided in the following manner for added convenience: Serum, IgG Fraction, Affinity Purified as well as labeled with Biotin or FITC. This antibody reacts with both free and complexed forms of uPA.
The optimal working dilution should be determined by the end user.
In 50 mM sodium phosphate buffer, 150 mM NaCl, pH 7.4
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
OTTHUMP00000019849,U-plasminogen activator,antagonist of uPA,plasminogen activator, urinary,urokinase plasminogen activator,urokinase-type plasminogen activator amino-terminal fragment