Rabbit polyclonal antibody raised against recombinant CYP1A2.
Recombinant protein corresponding to human CYP1A2.
Western Blots: Recognizes P450 1A2 in human liver microsomes. Reacts with ≥ 0.2 ug of recombinant human cytochromes P450 1A2. Does not cross react with recombinant human cytochromes P450 2E1, 3A4, or 2C10.
Western Blot (1:1000) The optimal working dilution should be determined by the end user.
In 20 mM phosphate buffer, pH 8.0
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq
P450 form 4,aryl hydrocarbon hydroxylase,cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2,dioxin-inducible P3-450,flavoprotein-linked monooxygenase,microsomal monooxygenase,xenobiotic monooxygenase