GSTM1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant GSTM1.
Immunogen
Recombinant protein corresponding to human GSTM1.
Host
Rabbit
Reactivity
Human, Rat
Specificity
This antibody reacts specifically with GSTs of the mu class and does not cross react with alpha or pi class GSTs.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In unpurified antiserum
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
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Gene Info — GSTM1
Entrez GeneID
2944Gene Name
GSTM1
Gene Alias
GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MGC26563, MU, MU-1
Gene Description
glutathione S-transferase mu 1
Omim ID
138350Gene Ontology
HyperlinkGene Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq
Other Designations
GST class-mu 1|HB subunit 4|OTTHUMP00000013346|OTTHUMP00000013347|S-(hydroxyalkyl)glutathione lyase|glutathione S-alkyltransferase|glutathione S-aralkyltransferase|glutathione S-aryltransferase|glutathione S-transferase M1
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Publication Reference
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Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data.
Holmes J, Wareing C, Jacobs A, Hayes JD, Padua RA, Wolf CR.
British Journal of Cancer 1990 Aug; 62(2):209.
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Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data.
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