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Last updated: 2017/8/13
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TNFSF11 polyclonal antibody

  • Catalog # : PAB13566
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against recombinant TNFSF11.
  • Immunogen:
  • Recombinant protein corresponding to human TNFSF11.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes human RANKL. Detects a band of ~35 KDa by Western blot.
  • Form:
  • Liquid
  • Recommend Usage:
  • ELISA (1:2000-1:10000)
    Flow Cytometry (1:500-1:1000)
    Western Blot (1:2000-1:5000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of TNFSF11 with TNFSF11 polyclonal antibody (Cat # PAB13566) at 1 : 5,000 dilution.
    Lane 1 : TNFSF11-pET fusion protein.
    Lane 2 : TNFSF11-GST fusion protein.
    Lane 3 : Con-A activated human T lymphocytes lysate.
  • ELISA
  • Flow Cytometry
  • Flow Cytometry
  • Human TNFSF11 transfected HEK 293 cells were stained significantly by TNFSF11 polyclonal antibody (Cat # PAB13566).
  • Application Image
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8600
  • Gene Name:
  • TNFSF11
  • Gene Alias:
  • CD254,ODF,OPGL,OPTB2,RANKL,TRANCE,hRANKL2,sOdf
  • Gene Description:
  • tumor necrosis factor (ligand) superfamily, member 11
  • Gene Summary:
  • This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000178585,TNF-related activation-induced cytokine,osteoclast differentiation factor,osteoprotegerin ligand,receptor activator of nuclear factor kappa B ligand,tumor necrosis factor ligand superfamily, member 11
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