Collagen V polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against native COL5A1/COL5A2/COL5A3.
Immunogen
Native purified COL5A1/COL5A2/COL5A3 from human placenta.
Host
Rabbit
Reactivity
Bovine, Human, Pig
Specificity
This antibody reacts with human collagen type V 100% binding in RIA at 1:100 dilution, cross-reactivity with human collagen type I, III and IV <0.1%; human fibronectin and laminin <0.1%.
Form
Lyophilized
Recommend Usage
ELISA (>1:200)
Immunohistochemistry (1:500)
Immunofluorescence (1:80)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at -20°C.
Aliquot after reconstitution to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
Radioimmunoassay
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Gene Info — COL5A1
Entrez GeneID
1289Gene Name
COL5A1
Gene Alias
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Gene Description
collagen, type V, alpha 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq
Other Designations
OTTHUMP00000022513|OTTHUMP00000064637|alpha 1 type V collagen
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Gene Info — COL5A2
Entrez GeneID
1290Gene Name
COL5A2
Gene Alias
MGC105115
Gene Description
collagen, type V, alpha 2
Gene Ontology
HyperlinkGene Summary
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq
Other Designations
AB collagen|Collagen V, alpha-2 polypeptide|alpha 2 type V collagen|collagen, fetal membrane, A polypeptide|type V preprocollagen alpha 2 chain
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Gene Info — COL5A3
Entrez GeneID
50509Gene Name
COL5A3
Gene Alias
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Gene Description
collagen, type V, alpha 3
Omim ID
120216Gene Ontology
HyperlinkGene Summary
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq
Other Designations
OTTHUMP00000195993|pro-(alpha)3(V) collagen
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