CFLAR polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CFLAR.
Immunogen
A synthetic peptide corresponding to N-terminus of human CFLAR.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
The sequence is identical in all FLIP splice variants. FLIP recognizes all FLIP splice variants including FLIPa, b, and y.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CFLAR in K-562 cell lysate with CFLAR polyclonal antibody (Cat # PAB13441) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of CFLAR in HeLa cells with CFLAR polyclonal antibody (Cat # PAB13441) at 5 ug/mL . -
Gene Info — CFLAR
Entrez GeneID
8837Protein Accession#
AAC51622Gene Name
CFLAR
Gene Alias
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS
Gene Description
CASP8 and FADD-like apoptosis regulator
Omim ID
603599Gene Ontology
HyperlinkOther Designations
FADD-like anti-apoptotic molecule|caspase-related inducer of apoptosis|inhibitor of FLICE|usurpin beta
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Interactome
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Pathway
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Disease
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Publication Reference
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I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.
Hu S, Vincenz C, Ni J, Gentz R, Dixit VM.
The Journal of Biological Chemistry 1997 Jul; 272(28):17255.
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Inhibition of death receptor signals by cellular FLIP.
Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J.
Nature 1997 Jul; 388(6638):190.
Application:IHC, WB-Tr, Human, HEK 293T cells, Human malignant melanoma cells, Human malignant melanoma tissues.
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Casper is a FADD- and caspase-related inducer of apoptosis.
Shu HB, Halpin DR, Goeddel DV.
Immunity 1997 Jun; 6(6):751.
Application:IP-WB, Human, 293 cells.
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I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.
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