LASS5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LASS5.
Immunogen
A synthetic peptide corresponding to N-terminus 18 amino acids of human LASS5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of LASS5 in rat brain tissue lysate with LASS5 polyclonal antibody (Cat # PAB13440) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemical staining of human brain tissue with 2.5 ug/mL LASS5 polyclonal antibody (Cat # PAB13440). -
Gene Info — LASS5
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Interactome
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Publication Reference
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siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI.
Anticancer research 2012 Jul; 32(7):2479.
Application:WB-Tr, Human, UM-SCC-22A cells.
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Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI.
Anticancer Research 2012 Mar; 32(3):753.
Application:WB-Ce, Human, Treated UM-SCC-22A.
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Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.
Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM.
The Journal of Biological Chemistry 2006 Nov; 281(45):33931.
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LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
Lahiri S, Futerman AH.
The Journal of Biological Chemistry 2005 Aug; 280(40):33735.
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Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
Riebeling C, Allegood JC, Wang E, Merrill AH Jr, Futerman AH.
The Journal of Biological Chemistry 2003 Oct; 278(44):43452.
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siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
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