TSLP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TSLP.
Immunogen
A synthetic peptide corresponding to internal region 19 amino acids of human TSLP.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TSLP in A-20 cell lysate with TSLP polyclonal antibody (Cat # PAB13435) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TSLP in human brain tissue with TSLP polyclonal antibody (Cat # PAB13435) at 2.5 ug/mL . -
Gene Info — TSLP
Entrez GeneID
85480Protein Accession#
NP_149024Gene Name
TSLP
Gene Alias
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Gene Description
thymic stromal lymphopoietin
Omim ID
607003Gene Ontology
HyperlinkGene Summary
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq
Other Designations
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Pathway
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Disease
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Publication Reference
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Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation.
Quentmeier H, Drexler HG, Fleckenstein D, Zaborski M, Armstrong A, Sims JE, Lyman SD.
Leukemia 2001 Aug; 15(8):1286.
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Molecular cloning and biological characterization of a novel murine lymphoid growth factor.
Sims JE, Williams DE, Morrissey PJ, Garka K, Foxworthe D, Price V, Friend SL, Farr A, Bedell MA, Jenkins NA, Copeland NG, Grabstein K, Paxton RJ.
The Journal of Experimental Medicine 2000 Sep; 192(5):671.
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Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism.
Levin SD, Koelling RM, Friend SL, Isaksen DE, Ziegler SF, Perlmutter RM, Farr AG.
The Journal of Immunology 1999 Jan; 162(2):677.
Application:Added, Recombinant protein.
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Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation.
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