CD180 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of CD180 in human spleen tissue lysate with CD180 polyclonal antibody (Cat # PAB13432) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CD180 in human spleen tissue with CD180 polyclonal antibody (Cat # PAB13432) at 2 ug/mL .
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CD180.
Immunogen
A synthetic peptide corresponding to N-terminus 11 amino acids of human CD180.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of CD180 in human spleen tissue lysate with CD180 polyclonal antibody (Cat # PAB13432) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CD180 in human spleen tissue with CD180 polyclonal antibody (Cat # PAB13432) at 2 ug/mL . -
Gene Info — CD180
Entrez GeneID
4064Protein Accession#
BAA12019Gene Name
CD180
Gene Alias
LY64, Ly78, MGC126233, MGC126234, RP105
Gene Description
CD180 molecule
Omim ID
602226Gene Ontology
HyperlinkGene Summary
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq
Other Designations
CD180 antigen|lymphocyte antigen-64, radioprotective, 105kDa
-
Interactome
-
Disease
-
Publication Reference
-
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K.
Journal of Immunology 2005 Jun; 174(11):7043.
-
Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, Kurt-Jones EA, Karp CL.
Journal of Endotoxin Research 2005 Jan; 11(6):363.
-
Innate immune recognition.
Janeway CA Jr, Medzhitov R.
Annual Review of Immunology 2001 Oct; 20:197.
-
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com