ERN1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of ERN1 in A-20 cell lysate with ERN1 polyclonal antibody (Cat # PAB13425) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunocytochemistry
Immunocytochemistry of ERN1 in A-20 cells with ERN1 polyclonal antibody (Cat # PAB13425) at 1 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ERN1.
Immunogen
A synthetic peptide corresponding to N-terminus 15 amino acids of human ERN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ERN1 in A-20 cell lysate with ERN1 polyclonal antibody (Cat # PAB13425) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of ERN1 in A-20 cells with ERN1 polyclonal antibody (Cat # PAB13425) at 1 ug/mL . -
Gene Info — ERN1
Entrez GeneID
2081Protein Accession#
O75460Gene Name
ERN1
Gene Alias
FLJ30999, IRE1, IRE1P, MGC163277, MGC163279
Gene Description
endoplasmic reticulum to nucleus signaling 1
Omim ID
604033Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq
Other Designations
ER to nucleus signalling 1|endoplasmic reticulum to nucleus signalling 1|inositol-requiring 1|protein kinase/endoribonuclease
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Interactome
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Disease
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Publication Reference
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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress.
Lee AS.
Methods 2005 Apr; 35(4):373.
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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response.
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D.
Nature Cell Biology 2000 Jun; 2(6):326.
Application：WB-Ce, Mouse, AR42J cells, Gastric mucosa.
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The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications.
Little E, Ramakrishnan M, Roy B, Gazit G, Lee AS.
Crit Rev Eukaryot Gene Expr 1994 Jan; 4(1):1.
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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress.
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