RPTOR polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of RPTOR in L1210 cell lysate with RPTOR polyclonal antibody (Cat # PAB13419) at (A) 2 and (B) 4 ug/mL .
Immunocytochemistry
Immunocytochemistry staining of L1210 cells using RPTOR polyclonal antibody (Cat # PAB13419) at 1 ug/mL
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RPTOR.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human RPTOR.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
Raptor has multiple isoforms that may also be recognized by antibody.
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of RPTOR in L1210 cell lysate with RPTOR polyclonal antibody (Cat # PAB13419) at (A) 2 and (B) 4 ug/mL .Immunocytochemistry
Immunocytochemistry staining of L1210 cells using RPTOR polyclonal antibody (Cat # PAB13419) at 1 ug/mL -
Gene Info — RPTOR
Entrez GeneID
57521Protein Accession#
Q8N122Gene Name
RPTOR
Gene Alias
KOG1, Mip1
Gene Description
regulatory associated protein of MTOR, complex 1
Omim ID
607130Gene Ontology
HyperlinkGene Summary
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats|regulatory associated protein of mTOR
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Interactome
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Pathway
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Disease
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Publication Reference
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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.
Fingar DC, Blenis J.
Oncogene 2004 Apr; 23(18):3151.
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Integration of growth factor and nutrient signaling: implications for cancer biology.
Shamji AF, Nghiem P, Schreiber SL.
Molecular Cell 2003 Aug; 12(2):271.
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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism.
Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J.
The Journal of Biological Chemistry 1998 Jun; 273(23):14484.
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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.
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