MCL1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MCL1 in Raji cell lysates with MCL1 polyclonal antibody (Cat # PAB13415) at (A) 1 and (B) 2 ug/mL .
Immunocytochemistry
Immunocytochemistry of MCL1 in Raji cells with MCL1 polyclonal antibody (Cat # PAB13415) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MCL1.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human MCL1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MCL1 in Raji cell lysates with MCL1 polyclonal antibody (Cat # PAB13415) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of MCL1 in Raji cells with MCL1 polyclonal antibody (Cat # PAB13415) at 10 ug/mL . -
Gene Info — MCL1
Entrez GeneID
4170Protein Accession#
NP_068779Gene Name
MCL1
Gene Alias
BCL2L3, EAT, MCL1L, MCL1S, MGC104264, MGC1839, TM
Gene Description
myeloid cell leukemia sequence 1 (BCL2-related)
Omim ID
159552Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq
Other Designations
OTTHUMP00000032794|OTTHUMP00000032795|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia sequence 1|myeloid cell leukemia sequence 1, isoform 1
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Interactome
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Disease
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Publication Reference
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Regulation of neutrophil apoptosis by Mcl-1.
Edwards SW, Derouet M, Howse M, Moots RJ.
Biochemical Society Transactions 2004 Jun; 32(Pt3):489.
Application：WB, Human, Human neutrophils.
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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells.
Cuconati A, Mukherjee C, Perez D, White E.
Genes & Development 2003 Dec; 17(23):2922.
Application：IP, WB, Human, HeLa cells.
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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW.
PNAS 1993 Apr; 90(8):3516.
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Regulation of neutrophil apoptosis by Mcl-1.
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