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Last updated: 2016/10/23
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GP6 polyclonal antibody

  • Catalog # : PAB13394
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of GP6.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus 15 amino acids of human GP6.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of GP6 in A-20 lysate with GP6 polyclonal antibody (Cat # PAB13394) at 1 ug/m in either the absence or (B) the presence of blocking peptide.
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical staining of human heart tissue with 10 ug/mL GP6 polyclonal antibody (Cat # PAB13394).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • GP6
  • Gene Alias:
  • GPIV,GPVI,MGC138168
  • Gene Description:
  • glycoprotein VI (platelet)
  • Gene Summary:
  • Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM
  • Other Designations:
  • platelet collagen receptor,platelet glycoprotein VI
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