GP6 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of GP6 in A-20 lysate with GP6 polyclonal antibody (Cat # PAB13394) at 1 ug/m in either the absence or (B) the presence of blocking peptide.
Immunohistochemistry
Immunohistochemical staining of human heart tissue with 10 ug/mL GP6 polyclonal antibody (Cat # PAB13394).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GP6.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human GP6.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of GP6 in A-20 lysate with GP6 polyclonal antibody (Cat # PAB13394) at 1 ug/m in either the absence or (B) the presence of blocking peptide.Immunohistochemistry
Immunohistochemical staining of human heart tissue with 10 ug/mL GP6 polyclonal antibody (Cat # PAB13394). -
Gene Info — GP6
Entrez GeneID
51206Protein Accession#
NP_057447Gene Name
GP6
Gene Alias
GPIV, GPVI, MGC138168
Gene Description
glycoprotein VI (platelet)
Omim ID
605546Gene Ontology
HyperlinkGene Summary
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM
Other Designations
platelet collagen receptor|platelet glycoprotein VI
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Interactome
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Pathway
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Disease
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Publication Reference
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Eltrombopag Enhances Platelet Adhesion by Up-regulating the Expression of Glycoprotein VI in Patients with Chronic Immune Thrombocytopenic Purpura.
Chiou TJ, Chang YF, Wang MC, Kao CW, Lin HY, Chen TY, Hsueh EJ, Lan YJ, Sung YC, Lin SF, Bai LY, Chen CG.
Translational Research 2015 Dec; 166(6):750.
Application：WB, Human, Megakaryocytic cell.
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Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2.
Inoue O, Suzuki-Inoue K, Dean WL, Frampton J, Watson SP.
The Journal of Cell Biology 2003 Mar; 160(5):769.
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Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.
Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL.
Blood 2000 Sep; 96(5):1798.
Application：WB-Ce, WB-Tr, Human, Mouse, Platelets, U937, CHO cells.
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The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors.
Clemetson JM, Polgar J, Magnenat E, Wells TN, Clemetson KJ.
The Journal of Biological Chemistry 1999 Oct; 274(41):29019.
Application：Flow Cyt, Human, Dami cells.
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Eltrombopag Enhances Platelet Adhesion by Up-regulating the Expression of Glycoprotein VI in Patients with Chronic Immune Thrombocytopenic Purpura.
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