BICD2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BICD2.
Immunogen
A synthetic peptide corresponding to internal region 14 amino acids of human BICD2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BICD2 in A-549 cell lysate with BICD2 polyclonal antibody (Cat # PAB13388) at (A) 1 and (B) 2 ug/mL . -
Gene Info — BICD2
Entrez GeneID
23299Protein Accession#
CAI41013Gene Name
BICD2
Gene Alias
KIAA0699, bA526D8.1
Gene Description
bicaudal D homolog 2 (Drosophila)
Omim ID
609797Gene Ontology
HyperlinkGene Summary
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq
Other Designations
OTTHUMP00000022790|OTTHUMP00000022791|bicaudal D homolog 2|coiled-coil protein BICD2|cytoskeleton-like bicaudal D protein homolog 2|homolog of Drosophila bicaudal D
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Interactome
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Publication Reference
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A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice.
Teuling E, van Dis V, Wulf PS, Haasdijk ED, Akhmanova A, Hoogenraad CC, Jaarsma D.
Human Molecular Genetics 2008 Sep; 17(18):2849.
Application:WB-Ti, Mouse, Mouse spinal cord.
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Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.
Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD.
The Journal of Biological Chemistry 2002 May; 277(18):16229.
Application:IF, WB-Ce, WB-Tr, Human, HeLa, HT29 cells.
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Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.
Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N.
The EMBO Journal 2001 Aug; 20(15):4041.
Application:IEM, IF, IP, WB-Tr, Human, Monkey, COS-1, HeLa cells.
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A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice.
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