TMC8 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of TMC8 in rat thymus tissue lysate with TMC8 polyclonal antibody (Cat # PAB13386) at (A) 1 and (B) 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TMC8.
Immunogen
A synthetic peptide corresponding to N-terminus 18 amino acids of human TMC8.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TMC8 in rat thymus tissue lysate with TMC8 polyclonal antibody (Cat # PAB13386) at (A) 1 and (B) 2 ug/mL . -
Gene Info — TMC8
Entrez GeneID
147138Protein Accession#
AAM44454Gene Name
TMC8
Gene Alias
EV2, EVER2, EVIN2, FLJ40668, FLJ43684, MGC102701, MGC40121
Gene Description
transmembrane channel-like 8
Gene Ontology
HyperlinkGene Summary
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq
Other Designations
epidermodysplasia verruciformis 2
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Publication Reference
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Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.
Lazarczyk M, Pons C, Mendoza JA, Cassonnet P, Jacob Y, Favre M.
The Journal of Experimental Medicine 2007 Dec; 205(1):35.
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Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis.
Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M.
Nature Genetics 2002 Dec; 32(4):579.
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Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.
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