SCARB2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of SCARB2 in human skeletal muscle tissue lysate with SCARB2 polyclonal antibody (Cat # PAB13376) at 1 ug/mL in (A) the absence and (B) presence of blocking peptide.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of SCARB2 in human skeletal muscle with SCARB2 polyclonal antibody (Cat # PAB13376) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SCARB2.
Immunogen
A synthetic peptide corresponding to internal region 16 amino acids of human SCARB2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SCARB2 in human skeletal muscle tissue lysate with SCARB2 polyclonal antibody (Cat # PAB13376) at 1 ug/mL in (A) the absence and (B) presence of blocking peptide.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of SCARB2 in human skeletal muscle with SCARB2 polyclonal antibody (Cat # PAB13376) at 2.5 ug/mL . -
Gene Info — SCARB2
Entrez GeneID
950Protein Accession#
AAH21892Gene Name
SCARB2
Gene Alias
AMRF, CD36L2, HLGP85, LIMPII, SR-BII
Gene Description
scavenger receptor class B, member 2
Omim ID
602257Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. [provided by RefSeq
Other Designations
85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2|CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)|lysosomal integral membrane protein II
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Interactome
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Pathway
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Disease
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Publication Reference
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Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.
Knipper M, Claussen C, Rüttiger L, Zimmermann U, Lüllmann-Rauch R, Eskelinen EL, Schröder J, Schwake M, Saftig P.
The Journal of Physiology 2006 Oct; 576(Pt 1):73.
Application：IF, IHC-Fr, Mouse, Mouse spiral ganglion neurons, Stria vascularis.
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LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice.
Gamp AC, Tanaka Y, Lüllmann-Rauch R, Wittke D, D'Hooge R, De Deyn PP, Moser T, Maier H, Hartmann D, Reiss K, Illert AL, von Figura K, Saftig P.
Human Molecular Genetics 2003 Mar; 12(6):631.
Application：WB-Ti, Mouse, Brain, Heart, Kidney, Liver, Lung, Spleen, Thymus.
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Isolation and sequencing of a cDNA clone encoding 85kDa sialoglycoprotein in rat liver lysosomal membranes.
Fujita H, Ezaki J, Noguchi Y, Kono A, Himeno M, Kato K.
Biochemical and Biophysical Research Communications 1991 Jul; 178(2):444.
Application：SDS-PAGE, Recombinant protein.
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Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.
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