CADPS polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CADPS.
Immunogen
A synthetic peptide corresponding to N-terminus 21 amino acids of human CADPS.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CADPS in rat brain tissue lysate with CADPS polyclonal antibody (Cat # PAB13364) at (A) 0.25 and (B) 0.5 ug/mL .Immunohistochemistry
Immunohistochemical staining of human brain tissue with 5 ug/mL CADPS polyclonal antibody (Cat # PAB13364). -
Gene Info — CADPS
Entrez GeneID
8618Protein Accession#
NP_899631Gene Name
CADPS
Gene Alias
CADPS1, CAPS, CAPS1, KIAA1121
Gene Description
Ca++-dependent secretion activator
Omim ID
604667Gene Ontology
HyperlinkGene Summary
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq
Other Designations
Ca2+-dependent activator protein for secretion|Ca2+-dependent secretion activator|Ca2+-regulated cytoskeletal protein
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Interactome
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Disease
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Publication Reference
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CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
Jockusch WJ, Speidel D, Sigler A, Sorensen JB, Varoqueaux F, Rhee JS, Brose N.
Cell 2007 Nov; 131(4):796.
Application:WB-Ce, Mouse, Mouse hippocampal neurons.
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Rapid regulated dense-core vesicle exocytosis requires the CAPS protein.
Rupnik M, Kreft M, Sikdar SK, Grilc S, Romih R, Zupancic G, Martin TF, Zorec R.
PNAS 2000 May; 97(10):5627.
Application:IF, Rat, Melanotrophs.
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A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells.
Walent JH, Porter BW, Martin TF.
Cell 1992 Sep; 70(5):765.
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CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
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