TMC6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TMC6.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human TMC6.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TMC6 in human spleen tissue lysate with TMC6 polyclonal antibody (Cat # PAB13360) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TMC6 in human spleen with TMC6 polyclonal antibody (Cat # PAB13360) at 2.5 ug/mL . -
Gene Info — TMC6
Entrez GeneID
11322Protein Accession#
AAM44452Gene Name
TMC6
Gene Alias
EV1, EVER1, EVIN1, FLJ17776, LAK-4P
Gene Description
transmembrane channel-like 6
Gene Ontology
HyperlinkGene Summary
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq
Other Designations
epidermodysplasia verruciformis 1|expressed in activated T/LAK lymphocytes
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Interactome
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Disease
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Publication Reference
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Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.
Lazarczyk M, Pons C, Mendoza JA, Cassonnet P, Jacob Y, Favre M.
The Journal of Experimental Medicine 2007 Dec; 205(1):35.
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TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.
Keresztes G, Mutai H, Heller S.
BMC Genomics 2003 Jun; 4(1):24.
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Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: role in tumor progression.
Majewski S, Jabłońska S, Orth G.
Clinics in Dermatology 1997 May; 15(3):321.
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Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.
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