IRGM polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRGM.
Immunogen
A synthetic peptide corresponding to internal region 14 amino acids of human IRGM.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of IRGM in human brain tissue lysate with IRGM polyclonal antibody (Cat # PAB13358) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of IRGM in human brain with IRGM polyclonal antibody (Cat # PAB13358) at 5 ug/mL . -
Gene Info — IRGM
Entrez GeneID
345611Protein Accession#
AAI28169Gene Name
IRGM
Gene Alias
IFI1, IRGM1, LRG-47, LRG47, MGC149263, MGC149264
Gene Description
immunity-related GTPase family, M
Omim ID
608212Gene Ontology
HyperlinkGene Summary
Members of the p47 immunity-related GTPase (IRG) family, including IRGM, play an important role in the murine immune system; however, in humans this resistance system is greatly reduced. There is evidence that human IRGM plays a role in autophagy and control of intracellular mycobacteria (Bekpen et al., 2005; Singh et al., 2006 [PubMed 16888103]).[supplied by OMIM
Other Designations
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Interactome
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Disease
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Publication Reference
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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J.
Nature Genetics 2008 Jun; 40(6):710.
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Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease.
Massey DC, Parkes M.
Autophagy 2009 Nov; 3(6):649.
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Autophagy as a cell death and tumor suppressor mechanism.
Gozuacik D, Kimchi A.
Oncogene 2004 Apr; 23(16):2891.
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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
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