LGI1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of LGI1 in HeLa cell lysate with LGI1 polyclonal antibody (Cat # PAB13341) at 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue using LGI1 polyclonal antibody (Cat # PAB13341) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LGI1.
Immunogen
A synthetic peptide corresponding to internal region 14 amino acids of human LGI1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of LGI1 in HeLa cell lysate with LGI1 polyclonal antibody (Cat # PAB13341) at 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue using LGI1 polyclonal antibody (Cat # PAB13341) at 2.5 ug/mL . -
Gene Info — LGI1
Entrez GeneID
9211Protein Accession#
AAQ89244Gene Name
LGI1
Gene Alias
EPITEMPIN, EPT, ETL1, IB1099
Gene Description
leucine-rich, glioma inactivated 1
Gene Ontology
HyperlinkGene Summary
This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq
Other Designations
OTTHUMP00000020121|epilepsy, partial
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Interactome
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Disease
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Publication Reference
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CPA6, FMO2, LGI1, SIAT1 and TNC are differentially expressed in early- and late-stage oral squamous cell carcinoma--a pilot study.
Fialka F, Gruber RM, Hitt R, Opitz L, Brunner E, Schliephake H, Kramer FJ.
Oral Oncology 2008 Oct; 44(10):941.
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Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M.
Science 2006 Sep; 313(5794):1792.
Application：WB, Rat, Rat brains.
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A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors.
Chernova OB, Somerville RP, Cowell JK.
Oncogene 1998 Dec; 17(22):2873.
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CPA6, FMO2, LGI1, SIAT1 and TNC are differentially expressed in early- and late-stage oral squamous cell carcinoma--a pilot study.
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