SIRT2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of SIRT2 in human brain tissue lysate with SIRT2 polyclonal antibody (Cat # PAB13340) at (A) 2.5 and (B) 5 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue using SIRT2 polyclonal antibody (Cat # PAB13340) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SIRT2.
Immunogen
A synthetic peptide corresponding to N-terminus 17 amino acids of human SIRT2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (2.5-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SIRT2 in human brain tissue lysate with SIRT2 polyclonal antibody (Cat # PAB13340) at (A) 2.5 and (B) 5 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue using SIRT2 polyclonal antibody (Cat # PAB13340) at 2.5 ug/mL . -
Gene Info — SIRT2
Entrez GeneID
22933Protein Accession#
NP_036369Gene Name
SIRT2
Gene Alias
SIR2, SIR2L, SIR2L2
Gene Description
sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
Omim ID
604480Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene. [provided by RefSeq
Other Designations
silencing information regulator 2-like|silent information regulator 2|sir2-related protein type 2|sirtuin 2|sirtuin type 2
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Interactome
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Publication Reference
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The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.
Inoue T, Hiratsuka M, Osaki M, Oshimura M.
Cell Cycle 2007 May; 6(9):1011.
Application：IF, IP, WB-Tr, Human, Mammalian cells.
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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E.
Molecular Cell 2003 Feb; 11(2):437.
Application：IF, WB-Tr, Human, Fibroblasts, HEK 293T cells.
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Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
Frye RA.
Biochemical and Biophysical Research Communications 1999 Jun; 260(1):273.
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The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.
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