ATG12 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of ATG12 in mouse heart tissue lysate with ATG12 polyclonal antibody (Cat # PAB13322) at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry
Immunohistochemical staining of human brain tissue with 2.5 ug/mL ATG12 polyclonal antibody (Cat # PAB13322).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ATG12.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human ATG12.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ATG12 in mouse heart tissue lysate with ATG12 polyclonal antibody (Cat # PAB13322) at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.Immunohistochemistry
Immunohistochemical staining of human brain tissue with 2.5 ug/mL ATG12 polyclonal antibody (Cat # PAB13322). -
Gene Info — ATG12
Entrez GeneID
9140Protein Accession#
EAW48955Gene Name
ATG12
Gene Alias
APG12, APG12L, FBR93, HAPG12
Gene Description
ATG12 autophagy related 12 homolog (S. cerevisiae)
Omim ID
609608Gene Ontology
HyperlinkGene Summary
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM
Other Designations
APG12 autophagy 12-like|Apg12 (autophagy, yeast) homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.
Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y.
The Journal of Biological Chemistry 2007 Dec; 282(52):37298.
Application：WB-Re, Recombinant protein.
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Autophagy as a cell death and tumor suppressor mechanism.
Gozuacik D, Kimchi A.
Oncogene 2004 Apr; 23(16):2891.
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Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y.
Journal of Cellular Biology 2000 Sep; 150(6):1507.
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The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.
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