SP110 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of SP110 in SW480 cell lysate with SP110 polyclonal antibody (Cat # PAB13318) at (A) 1 and (B) 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SP110.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human SP110.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SP110 in SW480 cell lysate with SP110 polyclonal antibody (Cat # PAB13318) at (A) 1 and (B) 2 ug/mL . -
Gene Info — SP110
Entrez GeneID
3431Protein Accession#
NP_004501Gene Name
SP110
Gene Alias
FLJ22835, IFI41, IFI75, IPR1, VODI
Gene Description
SP110 nuclear body protein
Gene Ontology
HyperlinkGene Summary
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq
Other Designations
interferon-induced protein 41, 30kD|interferon-induced protein 75, 52kD|phosphoprotein 41|phosphoprotein 75|transcriptional coactivator Sp110
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Interactome
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Disease
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Publication Reference
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Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.
de la Fuente J, Manzano-Roman R, Blouin EF, Naranjo V, Kocan KM.
BMC Infectious Diseases 2007 Sep; 7:110.
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Ipr1 gene mediates innate immunity to tuberculosis.
Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I.
Nature 2005 Apr; 434(7034):767.
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Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator.
Bloch DB, Nakajima A, Gulick T, Chiche JD, Orth D, de La Monte SM, Bloch KD.
Molecular and Cellular Biology 2000 Aug; 20(16):6138.
Application：IF, IHC, WB-Tr, Human, HEp-2, NB4 cells.
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Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.
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