GRIK1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRIK1.
Immunogen
A synthetic peptide corresponding to internal region 16 amino acids of human GRIK1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of GRIK1 in rat brain tissue lysate with GRIK1 polyclonal antibody (Cat # PAB13312) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue using GRIK1 polyclonal antibody (Cat # PAB13312) at 2.5 ug/mL . -
Gene Info — GRIK1
Entrez GeneID
2897Protein Accession#
P39086Gene Name
GRIK1
Gene Alias
EAA3, EEA3, GLR5, GLUR5
Gene Description
glutamate receptor, ionotropic, kainate 1
Omim ID
138245Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000096569|excitatory amino acid receptor 3|glutamate receptor 5
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Kainate receptors.
Pinheiro P, Mulle C.
Cell and Tissue Research 2006 Jul; 326(2):457.
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A mosaic of functional kainate receptors in hippocampal interneurons.
Christensen JK, Paternain AV, Selak S, Ahring PK, Lerma J.
Journal of Neuroscience 2004 Oct; 24(41):8986.
Application:WB-Ti, Mouse, Mouse hippocampal homogenates.
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Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.
Bureau I, Bischoff S, Heinemann SF, Mulle C.
The Journal of Neuroscience 1999 Jan; 19(2):653.
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Kainate receptors.
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