ARMET polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ARMET.
Immunogen
A synthetic peptide corresponding to N-terminus 12 amino acids of human ARMET.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ARMET in rat brain tissue lysate with ARMET polyclonal antibody (Cat # PAB13302) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ARMET in human brain tissue with ARMET polyclonal antibody (Cat # PAB13302) at 2.5 ug/mL . -
Gene Info — ARMET
Entrez GeneID
7873Protein Accession#
P55145Gene Name
ARMET
Gene Alias
ARP, MANF, MGC142148, MGC142150
Gene Description
arginine-rich, mutated in early stage tumors
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon. [provided by RefSeq
Other Designations
arginine-rich protein
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Interactome
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Publication Reference
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Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.
Lindholm P, Voutilainen MH, Lauren J, Peranen J, Leppanen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M.
Nature 2007 Jul; 448(7149):73.
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MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons.
Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW.
Journal of Molecular Neuroscience 2003 Apr; 20(2):173.
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Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck.
Shridhar R, Shridhar V, Rivard S, Siegfried JM, Pietraszkiewicz H, Ensley J, Pauley R, Grignon D, Sakr W, Miller OJ, Smith DI.
Cancer Research 1996 Dec; 56(24):5576.
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Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.
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