ARMET polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of ARMET in mouse brain tissue lysate with ARMET polyclonal antibody (Cat # PAB13301) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ARMET in human brain tissue with ARMET polyclonal antibody (Cat # PAB13301) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ARMET.
Immunogen
A synthetic peptide corresponding to C-terminus 12 amino acids of human ARMET.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ARMET in mouse brain tissue lysate with ARMET polyclonal antibody (Cat # PAB13301) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ARMET in human brain tissue with ARMET polyclonal antibody (Cat # PAB13301) at 2.5 ug/mL . -
Gene Info — ARMET
Entrez GeneID
7873Protein Accession#
P55145Gene Name
ARMET
Gene Alias
ARP, MANF, MGC142148, MGC142150
Gene Description
arginine-rich, mutated in early stage tumors
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon. [provided by RefSeq
Other Designations
arginine-rich protein
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Interactome
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Publication Reference
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MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Anuradhika Puri, Terri A Pietka, Jothilingam Sivapackiam, Kendrah Kidd, Sun-Ji Park, Bryce G Johnson, Stanislav Kmoch, Jeremy S Duffield, Anthony J Bleyer, Meredith E Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen.
Nature Communications 2023 Oct; 14(1):6493.
Application：WB, IHC-P, IF, Human, Mouse, Kidney.
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MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy.
Yeawon Kim, Chuang Li, Chenjian Gu, Eric Tycksen, Anuradhika Puri, Terri A Pietka, Jothilingam Sivapackiam, Yili Fang, Kendrah Kidd, Sun-Ji Park, Bryce G Johnson, Stanislav Kmoch, Jeremy S Duffield, Anthony J Bleyer, Meredith E Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen.
bioRxiv : the Preprint Server for Biology 2023 Jan; [Epub].
Application：IF, Mouse, Mouse kidney.
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The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes.
José R Navarro-Betancourt, Joan Papillon, Julie Guillemette, Chen-Fang Chung, Takao Iwawaki, Andrey V Cybulsky.
Biochimica et Biophysica Acta. Molecular Basis of Disease 2022 Jun; 1868(6):166391.
Application：WB-Ce, WB-Tr, Mouse, Mouse kidney.
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Role of IRE1α in podocyte proteostasis and mitochondrial health.
José R Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Chen-Fang Chung, Andrey V Cybulsky.
Cell Death Discovery 2020 Nov; 6(1):128.
Application：WB-Ti, Mouse, Mouse kidney.
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A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome.
Mahadevan J, Morikawa S, Yagi T, Abreu D, Lu S, Kanekura K, Brown CM, Urano F.
Laboratory Investigation; a Journal of Technical Methods and Pathology 2020 Sep; 100(9):1197.
Application：IF, WB-Ce, WB-Tr, Mouse, Rat, INS-1 832/13 cells, Pancreatic.
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Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases.
Yeawon Kim, Heedoo Lee, Scott R Manson, Maria Lindahl, Bradley Evans, Jeffrey H Miner, Fumihiko Urano, Ying Maggie Chen.
Journal of the American Society of Nephrology 2016 Oct; 27(10):2974.
Application：WB, Mouse, Mouse urine specimens.
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Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.
Lindholm P, Voutilainen MH, Lauren J, Peranen J, Leppanen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M.
Nature 2007 Jul; 448(7149):73.
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MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons.
Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW.
Journal of Molecular Neuroscience 2003 Apr; 20(2):173.
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Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck.
Shridhar R, Shridhar V, Rivard S, Siegfried JM, Pietraszkiewicz H, Ensley J, Pauley R, Grignon D, Sakr W, Miller OJ, Smith DI.
Cancer Research 1996 Dec; 56(24):5576.
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MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
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