PTK7 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTK7.
Immunogen
A synthetic peptide corresponding to C-terminus 18 amino acids of human PTK7.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of PTK7 in (A) human colon, (B) mouse kidney and (C) rat liver tissue lysate with PTK7 polyclonal antibody (Cat # PAB13289) at 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PTK7 in human colon tissue with PTK7 polyclonal antibody (Cat # PAB13289) at 2.5 ug/mL . -
Gene Info — PTK7
Entrez GeneID
5754Protein Accession#
AAH71557Gene Name
PTK7
Gene Alias
CCK4
Gene Description
PTK7 protein tyrosine kinase 7
Omim ID
601890Gene Ontology
HyperlinkGene Summary
Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000039809|colon carcinoma kinase-4
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Interactome
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Publication Reference
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PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M.
Nature 2004 Jul; 430(6995):93.
Application:IF, IHC, Mouse, Sensory hair cells in the inner ear.
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High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets.
Müller-Tidow C, Schwäble J, Steffen B, Tidow N, Brandt B, Becker K, Schulze-Bahr E, Halfter H, Vogt U, Metzger R, Schneider PM, Büchner T, Brandts C, Berdel WE, Serve H.
Clinical Cancer Research 2004 Feb; 10(4):1241.
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Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma.
Easty DJ, Mitchell PJ, Patel K, Flørenes VA, Spritz RA, Bennett DC.
International Journal of Cancer 1997 Jun; 71(6):1061.
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PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
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