TBC1D10C polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of TBC1D10C in Daudi cell lysate with TBC1D10C polyclonal antibody (Cat # PAB13276) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TBC1D10C in human spleen tissue with TBC1D10C polyclonal antibody (Cat # PAB13276) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TBC1D10C.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human TBC1D10C.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TBC1D10C in Daudi cell lysate with TBC1D10C polyclonal antibody (Cat # PAB13276) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TBC1D10C in human spleen tissue with TBC1D10C polyclonal antibody (Cat # PAB13276) at 2.5 ug/mL . -
Gene Info — TBC1D10C
Entrez GeneID
374403Protein Accession#
NP_940919Gene Name
TBC1D10C
Gene Alias
CARABIN, FLJ00332, MGC46488
Gene Description
TBC1 domain family, member 10C
Omim ID
610831Gene Ontology
HyperlinkGene Summary
Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]).[supplied by OMIM
Other Designations
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Interactome
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Disease
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Publication Reference
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Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.
Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO.
Nature 2007 Jan; 445(7126):433.
Application：IP, WB, Human, Jurkat cells.
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Deciphering the pathway from the TCR to NF-kappaB.
Weil R, Israël A.
Cell Death and Differentiation 2006 May; 13(5):826.
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Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling.
Im SH, Rao A.
Molecules and Cells 2004 Aug; 18(1):1.
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Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.
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