NPAS3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of NPAS3 in SK-N-SH cell lysate with NPAS3 polyclonal antibody (Cat # PAB13262) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of NPAS3 in human brain tissue with NPAS3 polyclonal antibody (Cat # PAB13262) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NPAS3.
Immunogen
A synthetic peptide corresponding to N-terminus 28 amino acids of human NPAS3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NPAS3 in SK-N-SH cell lysate with NPAS3 polyclonal antibody (Cat # PAB13262) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of NPAS3 in human brain tissue with NPAS3 polyclonal antibody (Cat # PAB13262) at 5 ug/mL . -
Gene Info — NPAS3
Entrez GeneID
64067Protein Accession#
Q8IXF0Gene Name
NPAS3
Gene Alias
MOP6, PASD6, bHLHe12
Gene Description
neuronal PAS domain protein 3
Omim ID
609430Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000178811|basic-helix-loop-helix-PAS protein
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Interactome
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Disease
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Publication Reference
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Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice.
Brunskill EW, Ehrman LA, Williams MT, Klanke J, Hammer D, Schaefer TL, Sah R, Dorn GW 2nd, Potter SS, Vorhees CV.
The European Journal of Neuroscience 2005 Sep; 22(6):1265.
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Disruption of the neuronal PAS3 gene in a family affected with schizophrenia.
Kamnasaran D, Muir WJ, Ferguson-Smith MA, Cox DW.
Journal of Medical Genetics 2003 May; 40(5):325.
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Characterization of npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system.
Brunskill EW, Witte DP, Shreiner AB, Potter SS.
Mechanisms of Development 1999 Nov; 88(2):237.
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Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice.
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