RTN4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of RTN4 in mouse brain tissue lysate with RTN4 polyclonal antibody (Cat # PAB13260) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of RTN4 in mouse brain tissue with RTN4 polyclonal antibody (Cat # PAB13260) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RTN4.
Immunogen
A synthetic peptide corresponding to N-terminus 23 amino acids of human RTN4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of RTN4 in mouse brain tissue lysate with RTN4 polyclonal antibody (Cat # PAB13260) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of RTN4 in mouse brain tissue with RTN4 polyclonal antibody (Cat # PAB13260) at 2.5 ug/mL . -
Gene Info — RTN4
Entrez GeneID
57142Protein Accession#
NP_065393Gene Name
RTN4
Gene Alias
ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
Gene Description
reticulon 4
Omim ID
604475Gene Ontology
HyperlinkGene Summary
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq
Other Designations
Human NogoA|My043 protein|foocen|neurite growth inhibitor 220|neurite outgrowth inhibitor|neuroendocrine-specific protein C homolog|reticulon 5
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Interactome
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Disease
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Publication Reference
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Nogo in the injured spinal cord.
Schweigreiter R, Bandtlow CE.
Journal of Neurotrauma 2006 Mar; 23(3-4):384.
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Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis.
Dupuis L, Gonzalez de Aguilar JL, di Scala F, Rene F, de Tapia M, Pradat PF, Lacomblez L, Seihlan D, Prinjha R, Walsh FS, Meininger V, Loeffler JP.
Neurobiology of Disease 2002 Aug; 10(3):358.
Application：WB-Ti, Human, Human muscle biopsies.
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Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.
Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME.
Nature 2000 Jan; 403(6768):434.
Application：Func, Mouse, NIH/3T3 cells.
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Nogo in the injured spinal cord.
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