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Last updated: 2016/10/23
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VISA polyclonal antibody

  • Catalog # : PAB13252
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of VISA.
  • Immunogen:
  • A synthetic peptide corresponding to internal region 17 amino acids of human VISA.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of VISA in rat brain tissue lysate with VISA polyclonal antibody (Cat # PAB13252) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry of VISA in mouse brain tissue with VISA polyclonal antibody (Cat # PAB13252) at 2.5 ug/mL .
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Gene Name:
  • VISA
  • Gene Alias:
  • CARDIF,DKFZp547C224,DKFZp666M015,FLJ27482,FLJ35386,FLJ38051,FLJ41962,IPS-1,IPS1,KIAA1271,MAVS,MGC3260
  • Gene Description:
  • virus-induced signaling adapter
  • Gene Summary:
  • Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM
  • Other Designations:
  • CARD adapter inducing interferon-beta,OTTHUMP00000030141,interferon-beta promoter stimulator protein 1,mitochondrial anti-viral signaling protein,virus-induced signaling adapter variant 1b,virus-induced signaling adaptor variant 1a
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