VISA polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of VISA.
Immunogen
A synthetic peptide corresponding to N-terminus 13 amino acids of human VISA.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of VISA in A-20 cell lysate with VISA polyclonal antibody (Cat # PAB13251) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of VISA in human brain tissue with VISA polyclonal antibody (Cat # PAB13251) at 5 ug/mL . -
Gene Info — VISA
Entrez GeneID
57506Protein Accession#
NP_065797Gene Name
VISA
Gene Alias
CARDIF, DKFZp547C224, DKFZp666M015, FLJ27482, FLJ35386, FLJ38051, FLJ41962, IPS-1, IPS1, KIAA1271, MAVS, MGC3260
Gene Description
virus-induced signaling adapter
Omim ID
609676Gene Ontology
HyperlinkGene Summary
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM
Other Designations
CARD adapter inducing interferon-beta|OTTHUMP00000030141|interferon-beta promoter stimulator protein 1|mitochondrial anti-viral signaling protein|virus-induced signaling adapter variant 1b|virus-induced signaling adaptor variant 1a
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Interactome
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Disease
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Publication Reference
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Antiviral innate immunity pathways.
Seth RB, Sun L, Chen ZJ.
Cell Research 2006 Feb; 16(2):141.
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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J.
Nature 2005 Oct; 437(7062):1167.
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VISA is an adapter protein required for virus-triggered IFN-beta signaling.
Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB.
Molecular Cell 2005 Sep; 19(6):727.
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Antiviral innate immunity pathways.
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