C12orf5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of C12orf5 in MCF-7 cell lysate with C12orf5 polyclonal antibody (Cat # PAB13250) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of C12orf5 in human brain tissue with C12orf5 polyclonal antibody (Cat # PAB13250) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of C12orf5.
Immunogen
A synthetic peptide corresponding to internal region 19 amino acids of human C12orf5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of C12orf5 in MCF-7 cell lysate with C12orf5 polyclonal antibody (Cat # PAB13250) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of C12orf5 in human brain tissue with C12orf5 polyclonal antibody (Cat # PAB13250) at 2.5 ug/mL . -
Gene Info — C12orf5
Entrez GeneID
57103Protein Accession#
NP_065108Gene Name
C12orf5
Gene Alias
TIGAR
Gene Description
chromosome 12 open reading frame 5
Omim ID
610775Gene Ontology
HyperlinkGene Summary
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq
Other Designations
TP53-induced glycolysis and apoptosis regulator|transactivated by NS3TP2 protein
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Interactome
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Publication Reference
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The regulation of energy generating metabolic pathways by p53.
Corcoran CA, Huang Y, Sheikh MS.
Cancer Biology & Therapy 2006 Dec; 5(12):1610.
Application：WB, Human, Human mammalian cells.
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TIGAR, a p53-inducible regulator of glycolysis and apoptosis.
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH.
Cell 2006 Jul; 126(1):107.
Application：WB, Human, MCF-7, MRC5, RKO, RPE, U-2 OS cells.
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TP53: a key gene in human cancer.
Guimaraes DP, Hainaut P.
Biochimie 2002 Jan; 84(1):83.
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The regulation of energy generating metabolic pathways by p53.
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