IFIH1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of IFIH1 in Daudi cell lysate with IFIH1 polyclonal antibody (Cat # PAB13246) at (A) 1, (B) 2 and (C) 4 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of IFIH1 in human lymph node tissue with IFIH1 polyclonal antibody (Cat # PAB13246) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IFIH1.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human IFIH1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IFIH1 in Daudi cell lysate with IFIH1 polyclonal antibody (Cat # PAB13246) at (A) 1, (B) 2 and (C) 4 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of IFIH1 in human lymph node tissue with IFIH1 polyclonal antibody (Cat # PAB13246) at 5 ug/mL . -
Gene Info — IFIH1
Entrez GeneID
64135Protein Accession#
NP_071451Gene Name
IFIH1
Gene Alias
Hlcd, IDDM19, MDA-5, MDA5, MGC133047
Gene Description
interferon induced with helicase C domain 1
Gene Ontology
HyperlinkGene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. [provided by RefSeq
Other Designations
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|helicard|melanoma differentiation associated protein-5
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Interactome
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Disease
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Publication Reference
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Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses.
Hiscott J, Nguyen TL, Arguello M, Nakhaei P, Paz S.
Oncogene 2006 Oct; 25(51):6844.
Application：WB-Tr, Human, Human mammalian cells, Tumors.
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Pathogen recognition and innate immunity.
Akira S, Uematsu S, Takeuchi O.
Cell 2006 Feb; 124(4):783.
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The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.
Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S, Randall RE.
PNAS 2004 Nov; 101(49):17264.
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Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses.
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