DRAM polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of DRAM in 293 cell lysate with DRAM polyclonal antibody (Cat # PAB13245) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of DRAM in human liver tissue with DRAM polyclonal antibody (Cat # PAB13245) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DRAM.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human DRAM.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of DRAM in 293 cell lysate with DRAM polyclonal antibody (Cat # PAB13245) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of DRAM in human liver tissue with DRAM polyclonal antibody (Cat # PAB13245) at 2.5 ug/mL . -
Gene Info — DRAM
Entrez GeneID
55332Protein Accession#
AAH18435Gene Name
DRAM
Gene Alias
FLJ11259
Gene Description
damage-regulated autophagy modulator
Omim ID
610776Gene Ontology
HyperlinkGene Summary
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq
Other Designations
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Interactome
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Publication Reference
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TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells.
Chen MC, Chen CH, Liu YN, Wang HP, Pan SL, Teng CM.
Cancer Letters 2013 Aug; 336(2):370.
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DRAM links autophagy to p53 and programmed cell death.
Crighton D, Wilkinson S, Ryan KM.
Autophagy 2007 Jan; 3(1):72.
Application：WB-Ce, WB-Tr, Human, Human cancer cells, Human mammalian cells.
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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.
Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM.
Cell 2006 Jul; 126(1):121.
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Autophagy as a cell death and tumor suppressor mechanism.
Gozuacik D, Kimchi A.
Oncogene 2004 Apr; 23(16):2891.
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TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells.
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