GPR44 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of GPR44 in Jurkat cell lysate with GPR44 polyclonal antibody (Cat # PAB13243) at 1 ug/mL in (A) the absence and (B) presence of blocking peptide.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of GPR44 in human heart tissue with GPR44 polyclonal antibody (Cat # PAB13243) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GPR44.
Immunogen
A synthetic peptide corresponding to N-terminus 18 amino acids of human GPR44.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of GPR44 in Jurkat cell lysate with GPR44 polyclonal antibody (Cat # PAB13243) at 1 ug/mL in (A) the absence and (B) presence of blocking peptide.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of GPR44 in human heart tissue with GPR44 polyclonal antibody (Cat # PAB13243) at 2.5 ug/mL . -
Gene Info — GPR44
Entrez GeneID
11251Protein Accession#
NP_004769Gene Name
GPR44
Gene Alias
CD294, CRTH2, DP2
Gene Description
G protein-coupled receptor 44
Omim ID
604837Gene Ontology
HyperlinkGene Summary
G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM
Other Designations
chemoattractant receptor homologous molecule expressed on T helper type 2 cells|chemoattractant receptor-homologous molecule expressed on TH2 cells
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Interactome
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Disease
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Publication Reference
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Tumor stroma reaction-related gene signature predicts clinical outcome in human hepatocellular carcinoma.
Gao Q, Wang XY, Qiu SJ, Zhou J, Shi YH, Zhang BH, Fan J.
Cancer Sci 2011 Jun; 102:1522.
Application：IHC, Human, Hepatocellular carcinoma.
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Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment.
Chevalier E, Stock J, Fisher T, Dupont M, Fric M, Fargeau H, Leport M, Soler S, Fabien S, Pruniaux MP, Fink M, Bertrand CP, McNeish J, Li B.
Journal of Immunology 2005 Aug; 175(4):2056.
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Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.
Shichijo M, Sugimoto H, Nagao K, Inbe H, Encinas JA, Takeshita K, Bacon KB, Gantner F.
The Journal of Pharmacology and Experimental Therapeutics 2003 Nov; 307(2):518.
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CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s).
Nagata K, Hirai H, Tanaka K, Ogawa K, Aso T, Sugamura K, Nakamura M, Takano S.
FEBS Letters 1999 Oct; 459(2):195.
Application：Flow Cyt, Human, K562/neo, K562/B19 cells.
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Tumor stroma reaction-related gene signature predicts clinical outcome in human hepatocellular carcinoma.
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