BANF1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of BANF1 in mouse kidney tissue lysate with BANF1 polyclonal antibody (Cat # PAB13242) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunofluorescence
Immunofluorescence of BANF1 in human kidney tissue with BANF1 polyclonal antibody (Cat # PAB13242) at 20 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BANF1.
Immunogen
A synthetic peptide corresponding to N-terminus 19 amino acids of human BANF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of BANF1 in mouse kidney tissue lysate with BANF1 polyclonal antibody (Cat # PAB13242) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunofluorescence
Immunofluorescence of BANF1 in human kidney tissue with BANF1 polyclonal antibody (Cat # PAB13242) at 20 ug/mL . -
Gene Info — BANF1
Entrez GeneID
8815Protein Accession#
AAH05942Gene Name
BANF1
Gene Alias
BAF, BCRP1, D14S1460, MGC111161
Gene Description
barrier to autointegration factor 1
Omim ID
603811Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein
Other Designations
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Interactome
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Publication Reference
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Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.
Cai M, Huang Y, Ghirlando R, Wilson KL, Craigie R, Clore GM.
EMBO J 2001 Aug; 20(16):4399.
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LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction.
Furukawa K.
Journal of Cell Science 1999 Aug; 112(Pt 15):2485.
Application：IF, WB-Ce, Rat, FRSK cells.
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The barrier-to-autointegration protein is a host factor for HIV type 1 integration.
Chen H, Engelman A.
PNAS 1998 Dec; 95(26):15270.
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Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.
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