TMED10 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TMED10.
Immunogen
A synthetic peptide corresponding to C-terminus 19 amino acids of human TMED10.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TMED10 in Raji cell lysate with TMED10 polyclonal antibody (Cat # PAB13235) at (A) 0.5 and (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TMED10 in human brain tissue with TMED10 polyclonal antibody (Cat # PAB13235) at 2.5 ug/mL . -
Gene Info — TMED10
Entrez GeneID
10972Protein Accession#
AAD31941Gene Name
TMED10
Gene Alias
P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I
Gene Description
transmembrane emp24-like trafficking protein 10 (yeast)
Omim ID
605406Gene Ontology
HyperlinkGene Summary
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq
Other Designations
21 kDa transmembrane trafficking protein|transmembrane emp24 domain-containing protein 10
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Interactome
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Disease
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Publication Reference
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TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P.
Nature 2006 Apr; 440(7088):1208.
Application:WB-Tr, Human, HEK 293, Mouse brainsa, SH-SY5Y cells .
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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.
Journal of Neuroscience Research 2004 Aug; 77(3):309.
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Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking.
Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I.
The Journal of Biological Chemistry 1996 Jul; 271(29):17183.
Application:WB-Ce, WB-Re, WB-Ti, Rat, Rat pancreatic acinar cells, Rat tissuies, Recombinant proteins.
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TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
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