NCSTN polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of NCSTN in mouse brain tissue lysate with NCSTN polyclonal antibody (Cat # PAB13231) at (A) 0.5, (B) 1, and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of NCSTN in human brain tissue with NCSTN polyclonal antibody (Cat # PAB13231) at 5 ug/mL .
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NCSTN.
Immunogen
A synthetic peptide corresponding to C-terminus 17 amino acids of human NCSTN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of NCSTN in mouse brain tissue lysate with NCSTN polyclonal antibody (Cat # PAB13231) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of NCSTN in human brain tissue with NCSTN polyclonal antibody (Cat # PAB13231) at 5 ug/mL . -
Gene Info — NCSTN
Entrez GeneID
23385Protein Accession#
NP_056146Gene Name
NCSTN
Gene Alias
APH2, KIAA0253
Gene Description
nicastrin
Omim ID
605254Gene Ontology
HyperlinkGene Summary
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq
Other Designations
ATAG1874|OTTHUMP00000031839|anterior pharynx-defective 2
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
Nguyen V, Hawkins C, Bergeron C, Supala A, Huang J, Westaway D, St George-Hyslop P, Rozmahel R.
Brain Research 2006 May; 1086(1):76.
-
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.
Journal of Neuroscience Research 2004 Aug; 77(3):309.
-
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Selkoe DJ.
Trends in Cell Biology 1998 Nov; 8(11):447.
-
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com