PSENEN polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PSENEN in K-562 cell lysate with PSENEN polyclonal antibody (Cat # PAB13229) at (A) 0.5, (B) 1, and (C) 2 ug/mL .
Immunofluorescence
Immunofluorescence of PSENEN in K-562 cells with PSENEN polyclonal antibody (Cat # PAB13229) at 20 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PSENEN.
Immunogen
A synthetic peptide corresponding C-terminus to 13 amino acids of human PSENEN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PSENEN in K-562 cell lysate with PSENEN polyclonal antibody (Cat # PAB13229) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunofluorescence
Immunofluorescence of PSENEN in K-562 cells with PSENEN polyclonal antibody (Cat # PAB13229) at 20 ug/mL . -
Gene Info — PSENEN
Entrez GeneID
55851Protein Accession#
NP_758844Gene Name
PSENEN
Gene Alias
MDS033, MSTP064, PEN-2, PEN2
Gene Description
presenilin enhancer 2 homolog (C. elegans)
Omim ID
607632Gene Ontology
HyperlinkGene Summary
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq
Other Designations
hematopoietic stem/progenitor cells protein MDS033|presenilin enhancer 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.
Journal of Neuroscience Research 2004 Aug; 77(3):309.
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Translating cell biology into therapeutic advances in Alzheimer's disease.
Selkoe DJ.
Nature 1999 Jun; 399(6738 Suppl):A23.
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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Selkoe DJ.
Trends in Cell Biology 1998 Nov; 8(11):447.
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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
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