PTPN11 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTPN11.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human PTPN11.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PTPN11 in mouse skeletal muscle tissue lysate with PTPN11 polyclonal antibody (Cat # PAB13222) at (A) 0.5, (B) 1 and (C) 2 ug/mL . -
Gene Info — PTPN11
Entrez GeneID
5781Protein Accession#
NP_002825Gene Name
PTPN11
Gene Alias
BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Gene Description
protein tyrosine phosphatase, non-receptor type 11
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq
Other Designations
protein tyrosine phosphatase-2|protein-tyrosine phosphatase 2C
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Interactome
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Pathway
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Disease
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Publication Reference
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Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.
Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS.
Molecular and Cellular Biology 2006 Jun; 26(12):4664.
Application:WB-Ti, Mouse, Mouse liver.
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Protein-tyrosine phosphatases and cancer.
Ostman A, Hellberg C, Bohmer FD.
Nature Reviews. Cancer 2006 Apr; 6(4):307.
Application:WB, Human, Mammalian cells.
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Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway.
Yu Z, Ahmad S, Schwartz JL, Banville D, Shen SH.
The Journal of Biological Chemistry 1997 Mar; 272(1):7519.
Application:IP, Human, 293 cells.
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Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.
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