PAK2 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PAK2.
Immunogen
A synthetic peptide corresponding to N-terminus 14 amino acids of human PAK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PAK2 in Jurkat lysate with PAK2 polyclonal antibody (Cat # PAB13218) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PAK2 in mouse spleen tissue with PAK2 polyclonal antibody (Cat # PAB13218) at 10 ug/mL . -
Gene Info — PAK2
Entrez GeneID
5062Protein Accession#
NP_002568Gene Name
PAK2
Gene Alias
PAK65, PAKgamma
Gene Description
p21 protein (Cdc42/Rac)-activated kinase 2
Omim ID
605022Gene Ontology
HyperlinkGene Summary
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq
Other Designations
S6/H4 kinase|p21 (CDKN1A)-activated kinase 2|p21-activated kinase 2
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Interactome
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Disease
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Publication Reference
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Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events.
Vilas GL, Corvi MM, Plummer GJ, Seime AM, Lambkin GR, Berthiaume LG.
PNAS 2006 Apr; 103(17):6542.
Application:WB, Human, Jurkat T cells.
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p21-activated kinases: three more join the Pak.
Jaffer ZM, Chernoff J.
The International Journal of Biochemistry & Cell Biology 2002 Jul; 34(7):713.
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Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
Rudel T, Bokoch GM.
Science 1997 Jun; 276(5318):1571.
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Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events.
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